040-1 MS Time Lapse MRI

Identifier: 040-1 Title: MS Time Lapse MRI Subject: Multiple Sclerosis; Serial Brain MRI in Multiple Sclerosis Description: This time lapse video was assembled from serial T2- weighted MRI scans from a 25-year old woman with multiple sclerosis which had recently entered the secondary progressive phase. Scans were performed at 2-weekly intervals for three months then monthly intervals for a further six months. Gadolinium DTPA was injected on each occasion for the first 6 months and monthly thereafter. The areas of enhancement in T1- weighted scans have been superimposed in red on the T2 weighted scans. In the video one second represents approximately one week in the patient’s life. Three successively deeper planes are shown covering the same period. New lesions almost always begin with enhancement, representing a breakdown in the blood- brain barrier. Enhancement usually lasts 2-4 weeks. The lesions increase in size over this period then shrink. The waxing and waning element represents oedema. Re-enhancement occurs in some lesions. There is a tendency to temporal clustering of lesion activity. During the period of observation there were 97 separate episodes of activity but only three clinical relapses. This video is part of the Wray Collection in NOVEL, the Neuro-Ophthalmology Virtual Education Library. Please cite the source when using this video. NOVEL.utah.edu Copyright 2015. For further information regarding the rights to this collection, please visit http://library.med.utah.edu/NOVEL/about/copyright